The top 10 trials of the recent past are an interesting bunch highlighting some of the best and worst of evidence-based medicine. While they might not be all you need to know, they are some of what you need to know. Some are practice changing, some introduce new treatment paradigms that may change the way we practice in the near future. Sepsis trials, oxygen therapy in various forms, miracle cures, delirium-o-lysis, levosimendan, angiotensin-II, tranexamic acid, and decompressive craniectomy all feature. Anyone who doesn’t think that the literature is interesting is bonkers.