• Twitter
  • Facebook
  • Vimeo
  • FCUS Courses
  • Register for FCUS Course
  • Login
Intensive Care Network
  • About Us
    • What is the ICN?
    • The ICN Story
  • Events
  • Podcast Series
    • ICN Activities
      • ICN Hot cases
      • Semantic sMatter
      • ECG Proving Ground
      • Echo Cases
      • SMACC 2013
      • ICU Radiology Cases
      • Game Changing Evidence
  • Regional Networks
    • SIN
    • BIN
  • Exams
    • Primary ANZCA
      • Pharmacology
      • Physiology
    • Primary ACEM
      • Pharmacology
      • Physiology
      • Pathology
      • Anatomy
    • Fellowship CICM
      • Notes
      • Past Papers
    • Fellowship Paeds
      • Approaches to Questions
      • Clinical Exam
      • Core ICU
      • Clinical Governance
      • Medicine
      • Surgery
    • Fellowship ANZCA
      • Notes
      • Past Papers with Answers
  • Resources
    • Links
    • The ICN meta feed
    • Reviews
      • Courses
      • Conferences
      • Websites & Blogs
      • Books & Journals
    • Clinical Resources
      • Clinical Calculators
    • Non-clinical resources
      • Research
  • Discussion Forum
    • Main Page

Understanding Lactate – Paul Marik

Home Understanding Lactate – Paul Marik

Understanding Lactate

NOTE: starts on Slide 3

Summary by: Rosy Wang

Lactate has been viewed as a byproduct of anaerobic metabolism and an indicator of tissue hypoperfusion since the 1900s. This theory is still widely believed. Paul busts the myths surrounding lactic acidosis, anaerobic metabolism, tissue hypoxia and the role of lactate in sepsis.

Key take-away facts include:
– The production of lactate actually consumes hydrogen ions. Lactic acidosis is really lactic alkalosis.
– Lactate is produced physiologically and is a precursor for gluconeogenesis.
– During exercise, skeletal muscle exports lactate as the primary fuel for the heart and brain.
– At VO2max, intracellular oxygen stays the same. Anaerobic metabolism in cells only occur as a pre-terminal event. The exception is in complete arterial occlusion.
– Adrenaline promotes lactate production
– Lactate infusion has been shown to increase cardiac output in septic and cardiogenic shock
– Lactate is a survival advantage!

 

the podcast

the slides

Understanding Lactate - Paul Marik from Royal North Shore Hospital & UTS

Subscribe to the ICN Podcast

Subscribe to the SMACC Podcast

Share this
Surviving in the Wild - Justin HensleyInterprofessional Communication: Challenges and Opportunities - Walter Eppich
IPSN – Intensivist Parent Support Network WIN – Women in Intensive Care Network ICN UK ICN NZ ICN WA ICN VIC ICN NSW ICN QLD The ICN Story The Team Jellybean Podcasts ICN Blog SMACC Video SMACC Audio Video ECG Simulator by aclsmedicaltraining BASIC SCIENCE CLINIC Simulation Game Changing Evidence ICU Radiology Echo Guide ECHO Cases Clinical Cases EXAMHELP Jellybean Podcasts ICN Blog SMACC Video SMACC Audio Video CICM Fellowship ANZCA FELLOWSHIP PAEDS FELLOWSHIP EMERGENCY PRIMARY ANAESTHETICS PRIMARY End-o-bed-o-gram

  • About
    •  What is ICN
    •  The Team
    •  ICN NSW
    •  ICN QLD
    •  ICN VIC
    •  ICN WA
    •  ICN NZ
    •  ICN UK
  • Resources
    •  Lung US
    •  Exam Help
    •  Clinical Cases
    •  Echo Cases
    •  Echo Guide
    •  ICU Radiology
    •  Game Changing Evidence
    •  ICN Metafeed
    •  Simulation Resouces
  • Media
    •  SMACC Posters
    •  Audio
    •  Video
    •  Pecha Kuchas
  • Upskill
    •  Clinical Cases
    •  Echo Cases
    •  ICU Radiology
  • Exam Help
    •  End-o-Bed-o-Gram
    •  ICU Primary Exam
    •  CICM Fellowship
    •  ANZCA Fellowship
    •  Paeds Fellowship
    •  Emergency Primary
    •  Anaesthetics Primary

® 2025 The Intensive Care Network || All rights reserved || Disclaimer || Site Map || Contact ICN Support

Log in with your credentials

or     Create an account

Lost your password?

Forgot your details?

I remember my details

Create Account