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Use this calculator to estimate the clearance obtained with a CVVHD treatment, or to adjust the setup of the CVVHD machine for a targeted clearance.
– Step 1 : select the unknown parameter to be calculated (clik on the radio buttons on the left).
– Step 2 : enter the values of the remaining parameters.
– Step 3 : click “Calculate” button on top.
KoA in a property of the filter, and represents the permeability (diffusion capacity) of the filter (should be determined by manufacturer).
Partition Coefficient represents the fraction of the considered solute that is available for filtration (0 to 1, for 0 to 100% of free solute). Usefull for protein-bound solutes.
The targeted clearance is usually between 20 and 35 ml/kg/h for continuous hemofiltration.
The Filtered Fraction is the proportion of the plasma volume filtered during passage through the filter. A value <30% is usually desirable to avoid excessive hemoconcentration, which may increase the risk of clotting.