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Pearse on the OPTIMISE Trial

Home Pearse on the OPTIMISE Trial

Rupert Pearse talks to JICS Cast (James Day and Segun Olusanya) about how we can improving perioperative management of patients and the very interesting results from the OPTIMISE trial.

[az_box_icon animation_loading=”yes” animation_loading_effects=”move_left” icon=”font-icon-book” title=”References” position=”left”]
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  1. Pearse RM, Harrison DA, MacDonald N, Gillies MA, Blunt M, Ackland G, Grocott MPW, Ahern A, Griggs K, Scott R, Hinds C, Rowan K. Effect of a Perioperative, Cardiac Output-Guided Hemodynamic Therapy Algorithm On outcomes Following Major Gastrointestinal Surgery- A Randomized Clinical Trial and Systematic Review. JAMA 2014 (online first currently) May 19, 2014. http://jama.jamanetwork.com/article.aspx?articleid=1873985 . See the ESICM 2013 presentation here http://www.esicm.org/news-article/lives2013hottopics
  2. Grocott MPW, Pearse RM. Perioperative Medicine: The future of anaesthesia? BJA 108, 5: 723-726 (free full text at http://bja.oxfordjournals.org/content/108/5/723.long )
  3. Shoemaker WC, Appel PL, Kram HB, Waxman K, Lee TS. Prospective trial of supranormal values of survivors as therapeutic goals in high-risk surgical patients. Chest 1998: 94: 1176-86 (free full text at http://journal.publications.chestnet.org/data/Journals/CHEST/21586/1176.pdf )
  4. Gattinoni L, Brazzi L, Pelosi P, Latini R, Tognoni G, Pesenti A, Fumagalli R. A trial of Goal-Oriented Hemodynamic Therapy in Critically Ill patients. NEJM 1995; 333: 1025-1032 (free full text at http://www.nejm.org/doi/full/10.1056/NEJM199510193331601#t=article )
  5. All in a lather over TTM. http://lifeinthefastlane.com/all-in-a-lather-over-ttm/ (Last accessed 23/05/2014)
  6. Perner A et al. Hydroxyethyl Starch 130/0.42 versus Ringer’s Acetate in Severe Sepsis. NEJM 2012; 367: 124-134 (free full text at http://www.nejm.org/doi/full/10.1056/NEJMoa1204242#t=article )
  7. Myburgh JA et al. Hydroxyethyl Starch or Saline for Fluid Resuscitation in intensive Care. NEJM 2012; 367: 1901-1911 (free full text at http://www.nejm.org/doi/full/10.1056/NEJMoa1209759#t=article )
  8. Gillies MA, Habicher M, Jhanji S, Sander M, Mythen M, Hamilton M, Pearse RM. Incidence of postoperative death and acute kidney injury associated with IV 6% hydroxyethyl starch use: Systematic review and meta-analysis. BJA 112, 1: 25-34 (available online at http://bja.oxfordjournals.org/content/112/1/25.long- subscription only. Contact us for a copy)

 

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